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學(xué)習(xí)快評丨qibao666888　　研??(yan)究??(jiu)團(tuán)??(tuan)隊??(dui)通??(tong)過??(guo)基??(ji)因??(yin)編??(bian)輯?(ji)技??(ji)術(shù)?(shu)??，在??(zai)實??(shi)驗?(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源??(yuan)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中??(zhong)敲??(qiao)除??(chu)MEF2C基??(ji)因??(yin)??。??失??(shi)去??(qu)這??(zhe)個??(ge)“車??(che)速??(su)控??(kong)制??(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的?(de)細(xì)??(xi)胞??(bao)隨??(sui)之?(zhi)陷??(xian)入??(ru)混??(hun)亂??(luan)??，負(fù)??(fu)責(zé)??(ze)抑??(yi)制??(zhi)過??(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋?(dan)白??(bai)產(chǎn)??(chan)量?(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍??(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的??(de)關(guān)??(guan)鍵??(jian)制??(zhi)動?(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過??(guo)度??(du)活??(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個??(ge)如??(ru)同??(tong)汽??(qi)車??(che)“安??(an)全??(quan)鎖??(suo)”的??(de)關(guān)??(guan)鍵??(jian)分??(fen)子?(zi)一??(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會?(hui)在??(zai)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)?(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時??(shi)徹??(che)底??(di)釋??(shi)放??(fang)NF-κB信??(xin)號??(hao)通?(tong)路??(lu)??，繼??(ji)而??(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等??(deng)炎??(yan)癥??(zheng)因??(yin)子??(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如??(ru)同??(tong)自??(zi)動??(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)在??(zai)速??(su)控??(kong)系?(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時??(shi)進(jìn)??(jin)行??(xing)加??(jia)速?(su)??，會??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴(yán)??(yan)重??(zhong)破??(po)壞??(huai)??。　　丁??(ding)勝??(sheng)介??(jie)紹??(shao)說??(shuo)??，這??(zhe)個??(ge)分??(fen)子??(zi)就??(jiu)像??(xiang)一??(yi)把??(ba)特??(te)制??(zhi)的??(de)鑰??(yao)匙??(chi)??，能??(neng)夠??(gou)精??(jing)準(zhǔn)??(zhun)插??(cha)入??(ru)CDK2激??(ji)酶??(mei)的?(de)活??(huo)性??(xing)口??(kou)袋?(dai)??。??這??(zhe)個??(ge)機(jī)??(ji)制??(zhi)的??(de)調(diào)??(tiao)控??(kong)不??(bu)像??(xiang)傳??(chuan)統(tǒng)??(tong)抗??(kang)炎??(yan)藥??(yao)那??(na)樣??(yang)全??(quan)面??(mian)壓??(ya)制?(zhi)免?(mian)疫??(yi)系??(xi)統(tǒng)??(tong)??，因??(yin)此??(ci)不??(bu)會?(hui)影??(ying)響??(xiang)其??(qi)他??(ta)正??(zheng)常??(chang)細(xì)??(xi)胞??(bao)功??(gong)能??(neng)??。在??(zai)細(xì)??(xi)胞??(bao)實??(shi)驗?(yan)中??(zhong)??，BMS265246使?(shi)炎??(yan)癥??(zheng)因??(yin)子??(zi)水??(shui)平??(ping)在??(zai)12小?(xiao)時??(shi)內(nèi)??(nei)恢??(hui)復(fù)??(fu)至??(zhi)正??(zheng)常??(chang)范??(fan)圍??(wei)??，且??(qie)未??(wei)出??(chu)現(xiàn)??(xian)細(xì)??(xi)胞??(bao)毒??(du)性??(xing)??。。