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　　蛋??(dan)白??(bai)質??(zhi)是??(shi)由??(you)氨??(an)基??(ji)酸??(suan)序?(xu)列??(lie)構?(gou)成??(cheng)的??(de)??，氨??(an)基??(ji)酸??(suan)序??(xu)列?(lie)的??(de)長??(chang)度??(du)從??(cong)數(shù)??(shu)百??(bai)個??(ge)到??(dao)上??(shang)千??(qian)個??(ge)不??(bu)等??(deng)??。??AI時??(shi)代??(dai)??，數(shù)??(shu)據(jù)??(ju)是??(shi)推??(tui)動??(dong)技??(ji)術??(shu)進??(jin)步??(bu)的??(de)核??(he)心??(xin)資??(zi)源??(yuan)??，龐??(pang)大??(da)的?(de)蛋??(dan)白??(bai)質?(zhi)序??(xu)列??(lie)數(shù)??(shu)據(jù)??(ju)集??(ji)能?(neng)幫??(bang)助??(zhu)模??(mo)型??(xing)更??(geng)好??(hao)地??(di)理??(li)解??(jie)蛋??(dan)白??(bai)質?(zhi)的??(de)序??(xu)列?(lie)、結??(jie)構??(gou)和??(he)功??(gong)能??(neng)關??(guan)系??(xi)??。洪??(hong)亮??(liang)團??(tuan)隊??(dui)建?(jian)立??(li)的??(de)蛋??(dan)白??(bai)質??(zhi)序??(xu)列??(lie)數(shù)??(shu)據(jù)??(ju)集??(ji)Venus-Pod(Venus-Protein Outsize Dataset)含??(han)有??(you)近??(jin)90億??(yi)條??(tiao)蛋??(dan)白??(bai)質??(zhi)序??(xu)列??(lie)??，包??(bao)含??(han)數(shù)??(shu)億??(yi)個??(ge)功??(gong)能??(neng)標??(biao)簽??(qian)??，是??(shi)全??(quan)球??(qiu)數(shù)??(shu)據(jù)?(ju)規(guī)?(gui)模??(mo)最??(zui)大??(da)、功??(gong)能??(neng)批??(pi)注??(zhu)標??(biao)簽??(qian)最??(zui)多??(duo)的??(de)數(shù)??(shu)據(jù)??(ju)集??(ji)??，也??(ye)是??(shi)另??(ling)一??(yi)行??(xing)業(yè)??(ye)知??(zhi)名??(ming)模?(mo)型??(xing)——美??(mei)國??(guo)ESM-C模??(mo)型祝(xing)訓??(xun)練??(lian)用??(yong)的??(de)21億??(yi)蛋??(dan)白??(bai)質??(zhi)序??(xu)列??(lie)的??(de)4倍??(bei)體??(ti)量??(liang)??。　　“我??(wo)們??(men)訓??(xun)練??(lian)了?(le)Venus(啟??(qi)明??(ming)星??(xing))系??(xi)列??(lie)模??(mo)型??(xing)??，與??(yu)DeepMind團??(tuan)隊??(dui)的??(de)AlphaFold預??(yu)測??(ce)蛋?(dan)白?(bai)質??(zhi)結?(jie)構??(gou)不??(bu)同??(tong)??，這??(zhe)個??(ge)模??(mo)型祝(xing)學??(xue)習??(xi)自??(zi)然??(ran)界??(jie)蛋??(dan)白??(bai)質?(zhi)序??(xu)列??(lie)的??(de)組??(zu)織?(zhi)規(guī)??(gui)則??(ze)以?(yi)及??(ji)它??(ta)與?(yu)功??(gong)能??(neng)之?(zhi)間??(jian)的??(de)關??(guan)系?(xi)??，其??(qi)預??(yu)測??(ce)蛋??(dan)白??(bai)質?(zhi)突??(tu)變??(bian)功??(gong)能??(neng)的??(de)精??(jing)度??(du)位??(wei)居??(ju)行??(xing)業(yè)??(ye)榜??(bang)單??(dan)之??(zhi)首??(shou)??。??”洪??(hong)亮??(liang)說??(shuo)??，Venus系??(xi)列??(lie)模??(mo)型??(xing)具??(ju)備??(bei)兩??(liang)大?(da)核??(he)心??(xin)功??(gong)能??(neng)：“AI定??(ding)向?(xiang)進??(jin)化??(hua)”與??(yu)“AI挖??(wa)酶??(mei)”??。這??(zhe)些??(xie)超??(chao)常??(chang)規(guī)??(gui)功??(gong)能??(neng)的??(de)蛋??(dan)白??(bai)質??(zhi)在?(zai)生??(sheng)物??(wu)技??(ji)術??(shu)、醫(yī)??(yi)藥??(yao)研??(yan)發(fā)??(fa)和??(he)工??(gong)業(yè)祝(ye)生??(sheng)產(chǎn)??(chan)中??(zhong)具??(ju)有??(you)巨??(ju)大??(da)的??(de)應??(ying)用??(yong)潛??(qian)力??(li)??，能??(neng)夠??(gou)為??(wei)相??(xiang)關?(guan)領??(ling)域??(yu)帶??(dai)來??(lai)創(chuàng)??(chuang)新??(xin)和?(he)突??(tu)破??(po)??。VCXYGDCNOQqibao666888　　dan ??(dan)bai ??(bai)zhi ??(zhi)shi ??(shi)you ??(you)an ??(an)ji ??(ji)suan ??(suan)xu ?(xu)lie ??(lie)gou ?(gou)cheng ??(cheng)de ??(de)??，an ??(an)ji ??(ji)suan ??(suan)xu ??(xu)lie ?(lie)de ??(de)chang ??(chang)du ??(du)cong ??(cong)shu ??(shu)bai ??(bai)ge ??(ge)dao ??(dao)shang ??(shang)qian ??(qian)ge ??(ge)bu ??(bu)deng ??(deng)??。??AIshi ??(shi)dai ??(dai)??，shu ??(shu)ju ??(ju)shi ??(shi)tui ??(tui)dong ??(dong)ji ??(ji)shu ??(shu)jin ??(jin)bu ??(bu)de ??(de)he ??(he)xin ??(xin)zi ??(zi)yuan ??(yuan)??，pang ??(pang)da ??(da)de ?(de)dan ??(dan)bai ??(bai)zhi ?(zhi)xu ??(xu)lie ??(lie)shu ??(shu)ju ??(ju)ji ??(ji)neng ?(neng)bang ??(bang)zhu ??(zhu)mo ??(mo)xing ??(xing)geng ??(geng)hao ??(hao)di ??(di)li ??(li)jie ??(jie)dan ??(dan)bai ??(bai)zhi ?(zhi)de ??(de)xu ??(xu)lie ?(lie)、jie ??(jie)gou ??(gou)he ??(he)gong ??(gong)neng ??(neng)guan ??(guan)xi ??(xi)??。hong ??(hong)liang ??(liang)tuan ??(tuan)dui ??(dui)jian ?(jian)li ??(li)de ??(de)dan ??(dan)bai ??(bai)zhi ??(zhi)xu ??(xu)lie ??(lie)shu ??(shu)ju ??(ju)ji ??(ji)Venus-Pod(Venus-Protein Outsize Dataset)han ??(han)you ??(you)jin ??(jin)90yi ??(yi)tiao ??(tiao)dan ??(dan)bai ??(bai)zhi ??(zhi)xu ??(xu)lie ??(lie)??，bao ??(bao)han ??(han)shu ??(shu)yi ??(yi)ge ??(ge)gong ??(gong)neng ??(neng)biao ??(biao)qian ??(qian)??，shi ??(shi)quan ??(quan)qiu ??(qiu)shu ??(shu)ju ?(ju)gui ?(gui)mo ??(mo)zui ??(zui)da ??(da)、gong ??(gong)neng ??(neng)pi ??(pi)zhu ??(zhu)biao ??(biao)qian ??(qian)zui ??(zui)duo ??(duo)de ??(de)shu ??(shu)ju ??(ju)ji ??(ji)??，ye ??(ye)shi ??(shi)ling ??(ling)yi ??(yi)xing ??(xing)ye ??(ye)zhi ??(zhi)ming ??(ming)mo ?(mo)xing ??(xing)——mei ??(mei)guo ??(guo)ESM-Cmo ??(mo)xing 祝(xing)xun ??(xun)lian ??(lian)yong ??(yong)de ??(de)21yi ??(yi)dan ??(dan)bai ??(bai)zhi ??(zhi)xu ??(xu)lie ??(lie)de ??(de)4bei ??(bei)ti ??(ti)liang ??(liang)???！　　皐o ??(wo)men ??(men)xun ??(xun)lian ??(lian)le ?(le)Venus(qi ??(qi)ming ??(ming)xing ??(xing))xi ??(xi)lie ??(lie)mo ??(mo)xing ??(xing)??，yu ??(yu)DeepMindtuan ??(tuan)dui ??(dui)de ??(de)AlphaFoldyu ??(yu)ce ??(ce)dan ?(dan)bai ?(bai)zhi ??(zhi)jie ?(jie)gou ??(gou)bu ??(bu)tong ??(tong)??，zhe ??(zhe)ge ??(ge)mo ??(mo)xing 祝(xing)xue ??(xue)xi ??(xi)zi ??(zi)ran ??(ran)jie ??(jie)dan ??(dan)bai ??(bai)zhi ?(zhi)xu ??(xu)lie ??(lie)de ??(de)zu ??(zu)zhi ?(zhi)gui ??(gui)ze ??(ze)yi ?(yi)ji ??(ji)ta ??(ta)yu ?(yu)gong ??(gong)neng ??(neng)zhi ?(zhi)jian ??(jian)de ??(de)guan ??(guan)xi ?(xi)??，qi ??(qi)yu ??(yu)ce ??(ce)dan ??(dan)bai ??(bai)zhi ?(zhi)tu ??(tu)bian ??(bian)gong ??(gong)neng ??(neng)de ??(de)jing ??(jing)du ??(du)wei ??(wei)ju ??(ju)xing ??(xing)ye ??(ye)bang ??(bang)dan ??(dan)zhi ??(zhi)shou ??(shou)??。??”hong ??(hong)liang ??(liang)shuo ??(shuo)??，Venusxi ??(xi)lie ??(lie)mo ??(mo)xing ??(xing)ju ??(ju)bei ??(bei)liang ??(liang)da ?(da)he ??(he)xin ??(xin)gong ??(gong)neng ??(neng)：“AIding ??(ding)xiang ?(xiang)jin ??(jin)hua ??(hua)”yu ??(yu)“AIwa ??(wa)mei ??(mei)”??。zhe ??(zhe)xie ??(xie)chao ??(chao)chang ??(chang)gui ??(gui)gong ??(gong)neng ??(neng)de ??(de)dan ??(dan)bai ??(bai)zhi ??(zhi)zai ?(zai)sheng ??(sheng)wu ??(wu)ji ??(ji)shu ??(shu)、yi ??(yi)yao ??(yao)yan ??(yan)fa ??(fa)he ??(he)gong ??(gong)ye 祝(ye)sheng ??(sheng)chan ??(chan)zhong ??(zhong)ju ??(ju)you ??(you)ju ??(ju)da ??(da)de ??(de)ying ??(ying)yong ??(yong)qian ??(qian)li ??(li)??，neng ??(neng)gou ??(gou)wei ??(wei)xiang ??(xiang)guan ?(guan)ling ??(ling)yu ??(yu)dai ??(dai)lai ??(lai)chuang ??(chuang)xin ??(xin)he ?(he)tu ??(tu)po ??(po)??。