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學習快評丨qibao666888　　北??(bei)京??(jing)時??(shi)間??(jian)3月??(yue)25日??(ri)??，清??(qing)華??(hua)大??(da)學?(xue)藥??(yao)學??(xue)院?(yuan)丁??(ding)勝??(sheng)教??(jiao)授??(shou)團??(tuan)隊??(dui)在??(zai)國?(guo)際??(ji)頂??(ding)級??(ji)學??(xue)術(shù)??(shu)期??(qi)刊??(kan)《Immunity》發(fā)??(fa)表??(biao)突?(tu)破??(po)性??(xing)研??(yan)究??(jiu)??，首??(shou)次?(ci)揭??(jie)示??(shi)控??(kong)制?(zhi)小?(xiao)膠??(jiao)質(zhì)??(zhi)細??(xi)胞??(bao)“加??(jia)速??(su)—控??(kong)速??(su)”平??(ping)衡??(heng)的?(de)關(guān)??(guan)鍵??(jian)開??(kai)關(guān)??(guan)??，并??(bing)成??(cheng)功?(gong)從??(cong)2400多??(duo)種??(zhong)化??(hua)合??(he)物??(wu)中??(zhong)篩??(shai)選??(xuan)出??(chu)能??(neng)精??(jing)準??(zhun)修??(xiu)復(fù)??(fu)該??(gai)系??(xi)統(tǒng)??(tong)的??(de)藥??(yao)物?(wu)小??(xiao)分??(fen)子??(zi)BMS265246??。??在??(zai)動??(dong)物??(wu)實?(shi)驗??(yan)中??(zhong)??，這?(zhe)種??(zhong)新??(xin)型??(xing)CDK2抑??(yi)制??(zhi)劑??(ji)使??(shi)患??(huan)病??(bing)小??(xiao)鼠??(shu)的??(de)腦??(nao)部??(bu)炎??(yan)癥?(zheng)消??(xiao)退??(tui)??，社??(she)交??(jiao)和??(he)記??(ji)憶??(yi)功??(gong)能??(neng)基??(ji)本??(ben)恢??(hui)復(fù)??(fu)正??(zheng)常??(chang)??。這??(zhe)項??(xiang)發(fā)??(fa)現(xiàn)??(xian)不??(bu)僅??(jin)為??(wei)學??(xue)界?(jie)深?(shen)入??(ru)理?(li)解??(jie)細??(xi)胞??(bao)周??(zhou)期??(qi)蛋??(dan)白??(bai)調(diào)??(tiao)控?(kong)非??(fei)分??(fen)裂??(lie)細??(xi)胞??(bao)功??(gong)能??(neng)提??(ti)供??(gong)了??(le)嶄??(zhan)新??(xin)的??(de)實??(shi)例??(li)??，更?(geng)為??(wei)治??(zhi)療??(liao)十??(shi)多?(duo)種??(zhong)神?(shen)經(jīng)??(jing)疾??(ji)病??(bing)提??(ti)供??(gong)了??(le)全??(quan)新??(xin)路??(lu)徑??(jing)???！　∫??(yao)阻??(zu)止??(zhi)這??(zhe)場??(chang)細??(xi)胞??(bao)層??(ceng)面??(mian)的??(de)“暴??(bao)動??(dong)”??，關(guān)??(guan)鍵??(jian)在??(zai)于??(yu)修??(xiu)復(fù)??(fu)失??(shi)靈??(ling)的??(de)“車??(che)速??(su)控??(kong)制?(zhi)”系??(xi)統(tǒng)??(tong)??。??研??(yan)究?(jiu)團??(tuan)隊??(dui)構(gòu)??(gou)建??(jian)了??(le)獨??(du)特??(te)的??(de)藥??(yao)物??(wu)篩??(shai)選??(xuan)平??(ping)臺??(tai)??，用??(yong)熒?(ying)光??(guang)標??(biao)記??(ji)細??(xi)胞??(bao)狀??(zhuang)態(tài)??(tai)并??(bing)結(jié)??(jie)合??(he)人??(ren)工?(gong)智??(zhi)能??(neng)分??(fen)析??(xi)??，對??(dui)2404種??(zhong)化??(hua)合??(he)物??(wu)進??(jin)行??(xing)地??(di)毯??(tan)式??(shi)掃??(sao)描??(miao)??。經(jīng)??(jing)過??(guo)多??(duo)輪??(lun)篩??(shai)選??(xuan)??，一??(yi)個?(ge)代??(dai)號??(hao)為??(wei)BMS265246的??(de)小??(xiao)分??(fen)子??(zi)脫??(tuo)穎??(ying)而??(er)出??(chu)??。。