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學(xué)習(xí)快評丨qibao666888　　研??(yan)究??(jiu)團??(tuan)隊??(dui)通?(tong)過??(guo)基??(ji)因??(yin)編??(bian)輯??(ji)技??(ji)術(shù)??(shu)??，在??(zai)實?(shi)驗??(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源??(yuan)小??(xiao)膠??(jiao)質(zhì)??(zhi)細??(xi)胞?(bao)中??(zhong)敲??(qiao)除??(chu)MEF2C基??(ji)因??(yin)??。??失??(shi)去??(qu)這??(zhe)個??(ge)“車??(che)速?(su)控??(kong)制?(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的??(de)細??(xi)胞??(bao)隨??(sui)之??(zhi)陷??(xian)入??(ru)混??(hun)亂??(luan)??，負??(fu)責(zé)??(ze)抑??(yi)制?(zhi)過??(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋??(dan)白??(bai)產(chǎn)??(chan)量??(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束?(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常?(chang)活??(huo)躍??(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的??(de)關(guān)?(guan)鍵??(jian)制?(zhi)動?(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的?(de)過??(guo)度??(du)活?(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀?(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個??(ge)如??(ru)同?(tong)汽??(qi)車??(che)“安??(an)全??(quan)鎖??(suo)”的??(de)關(guān)??(guan)鍵??(jian)分?(fen)子??(zi)一??(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會??(hui)在??(zai)小??(xiao)膠??(jiao)質(zhì)??(zhi)細??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時?(shi)徹??(che)底?(di)釋??(shi)放??(fang)NF-κB信??(xin)號??(hao)通??(tong)路??(lu)??，繼??(ji)而?(er)引?(yin)發(fā)??(fa)TNF-α、IL-6等??(deng)炎??(yan)癥??(zheng)因??(yin)子??(zi)的?(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如??(ru)同??(tong)自??(zi)動??(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)在??(zai)速??(su)控?(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時??(shi)進??(jin)行??(xing)加??(jia)速??(su)??，會??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴(yán)??(yan)重??(zhong)破??(po)壞??(huai)??。　　要??(yao)阻??(zu)止??(zhi)這??(zhe)場??(chang)細?(xi)胞??(bao)層??(ceng)面?(mian)的??(de)“暴??(bao)動??(dong)”??，關(guān)??(guan)鍵??(jian)在??(zai)于??(yu)修??(xiu)復(fù)??(fu)失??(shi)靈??(ling)的??(de)“車??(che)速??(su)控??(kong)制??(zhi)”系?(xi)統(tǒng)??(tong)?。??研??(yan)究??(jiu)團??(tuan)隊??(dui)構(gòu)??(gou)建??(jian)了??(le)獨??(du)特??(te)的??(de)藥??(yao)物??(wu)篩??(shai)選??(xuan)平??(ping)臺?(tai)??，用??(yong)熒??(ying)光??(guang)標(biāo)??(biao)記??(ji)細??(xi)胞??(bao)狀??(zhuang)態(tài)??(tai)并??(bing)結(jié)??(jie)合??(he)人??(ren)工??(gong)智??(zhi)能??(neng)分??(fen)析??(xi)??，對?(dui)2404種??(zhong)化??(hua)合??(he)物??(wu)進??(jin)行??(xing)地??(di)毯??(tan)式?(shi)掃??(sao)描??(miao)?。經(jīng)??(jing)過??(guo)多??(duo)輪??(lun)篩??(shai)選??(xuan)??，一??(yi)個??(ge)代??(dai)號??(hao)為??(wei)BMS265246的??(de)小??(xiao)分??(fen)子??(zi)脫?(tuo)穎??(ying)而??(er)出??(chu)?。。